INTERNATIONAL GROUP OF ENDOVASCULAR ONCOLOGY (IGEVO)

OUR PLANS

IGEVO is starting now with 5 studies:

Liver mets from CRC

TACETUX ( DEBIRI PLUS CETUXIMAB)
PANDEBIRI ( DEBIRI PLUS PANITUMAB)

Hepatocellular Carcinoma

DEBDOX plus Sorafenib

Liver mets from Ocular Melanoma

DEBIRI

Melanoma and sarcoma relapses

Isolated Lımb cısplatın Infusıon

International registry on cholangiocarcinoma treated wıth DEBIRI/DEBDOX

PREVIOUS WORK

IGEVO has already published several papers in international journals:

Transarterial chemoembolization alone or followed by bevacizumab for treatment of colorectal liver metastases. Fiorentini G, Sarti D, Nardella M, Inchingolo R, Nestola M, Rebonato A, Fiorentini C, Aliberti C, Nani R, Guadagni S. Hepat Oncol. 2021 Jul 13;9(1):HEP40. doi: 10.2217/hep-2020-0031. PMID: 34765108; PMCID: PMC8577510.

Chemoembolization Alone or Associated With Bevacizumab for Therapy of Colorectal Cancer Metastases: Preliminary Results of a Randomized Study. Fiorentini G, Sarti D, Nardella M, Inchingolo R, Nestola M, Rebonato A, Guadagni S. In Vivo. 2020 Mar-Apr;34(2):683-686. doi: 10.21873/invivo.11824. PMID: 32111770; PMCID: PMC7157852.

A review discussing the use of polyethylene glycol microspheres in the treatment of hepatocellular carcinoma.

Fiorentini G, Sarti D, Carandina R, Mulazzani L, Mincarelli C, Candelari R, Argirò R, Fiorentini C, Aliberti C.

Future Oncol. 2019 Mar;15(7):695-703. doi: 10.2217/fon-2018-0425. Epub 2018 Nov 16.

Chemoembolization in Conjunction with Bevacizumab: Preliminary Results. Fiorentini G, Sarti D, Aliberti C, Carandina R, Mulazzani L, Felicioli A, Guadagni S. J Vasc Interv Radiol. 2018 Sep;29(9):1236-1239. doi: 10.1016/j.jvir.2018.04.022. PMID: 30146190.

Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer. Fiorentini G, Carandina R, Sarti D, Nardella M, Zoras O, Guadagni S, Inchingolo R, Nestola M, Felicioli A, Barnes Navarro D, Munoz Gomez F, Aliberti C. World J Gastrointest Oncol. 2017 Sep 15;9(9):379-384. doi: 10.4251/wjgo.v9.i9.379. PMID: 28979720; PMCID: PMC5605338.

Transarterial chemoembolization with DC Bead LUMI™ radiopaque beads for primary liver cancer treatment: preliminary experience. Aliberti C, Carandina R, Sarti D, Pizzirani E, Ramondo G, Cillo U, Guadagni S, Fiorentini G. Future Oncol. 2017 Oct;13(25):2243-2252. doi: 10.2217/fon-2017-0364. Epub 2017 Oct 24. PMID: 29063780.

Chemoembolization with Drug-eluting Microspheres Loaded with Doxorubicin for the Treatment of Cholangiocarcinoma. Aliberti C, Carandina R, Sarti D, Pizzirani E, Ramondo G, Mulazzani L, Mattioli GM, Fiorentini G. Anticancer Res. 2017 Apr;37(4):1859-1863. doi: 10.21873/anticanres.11522. PMID: 28373452.

Multidisciplinary approach of colorectal cancer liver metastases. Fiorentini G, Sarti D, Aliberti C, Carandina R, Mambrini A, Guadagni S. World J Clin Oncol. 2017 Jun 10;8(3):190-202. doi: 10.5306/wjco.v8.i3.190. PMID: 28638789; PMCID: PMC5465009.

Chemoembolization Adopting Polyethylene Glycol Drug-Eluting Embolics Loaded With Doxorubicin for the Treatment of Hepatocellular Carcinoma. Aliberti C, Carandina R, Sarti D, Mulazzani L, Pizzirani E, Guadagni S, Fiorentini G. AJR Am J Roentgenol. 2017 Aug;209(2):430-434. doi: 10.2214/AJR.16.17477. Epub 2017 May 24. PMID: 28537756.

Chemoembolization in colorectal liver metastases: the rebirth. Fiorentini G, Aliberti C, Mulazzani L, Coschiera P, Catalano V, Rossi D, Giordani P, Ricci S. Anticancer Res. 2014 Feb;34(2):575-84. PMID: 24510986.

Intra-arterial infusion of irinotecan-loaded drug-eluting beads (DEBIRI) versus intravenous therapy (FOLFIRI) for hepatic metastases from colorectal cancer: final results of a phase III study.

Fiorentini G, Aliberti C, Tilli M, Mulazzani L, Graziano F, Giordani P, Mambrini A, Montagnani F, Alessandroni P, Catalano V, Coschiera P.

Anticancer Res. 2012 Apr;32(4):1387-95.

Trans-arterial chemoembolization of metastatic colorectal carcinoma to the liver adopting DC Bead®, drug-eluting bead loaded with irinotecan: results of a phase II clinical study.

Aliberti C, Fiorentini G, Muzzio PC, Pomerri F, Tilli M, Dallara S, Benea G.

Anticancer Res. 2011 Dec;31(12):4581-7.

Systemic gemcitabine and capecitabine plus intra-arterial epirubicin and cisplatin as second-line chemotherapy in gemcitabine-failure pancreatic cancer.

Mambrini A, Bassi C, Torri T, Orlandi M, Fiorentini G, Cantore M.

Pancreas. 2011 Aug;40(6):983-4. doi: 10.1097/MPA.0b013e3182164002.

Selective arterial embolisation for bone tumours: experience of 454 cases.

Rossi G, Mavrogenis AF, Rimondi E, Ciccarese F, Tranfaglia C, Angelelli B, Fiorentini G, Bartalena T, Errani C, Ruggieri P, Mercuri M.

Radiol Med. 2011 Aug;116(5):793-808.

A new tool to enhance the efficacy of chemoembolization to treat primary and metastatic hepatic tumors.

Fiorentini G.

Expert Opin Drug Deliv. 2011 Apr;8(4):409-13. doi: 10.1517/17425247.2011.565327. Epub 2011 Mar 18.

Prognostic factors in patients with advanced pancreatic adenocarcinoma treated with intra-arterial chemotherapy.

Mambrini A, Bassi C, Pacetti P, Torri T, Iacono C, Ballardini M, Orlandi M, Guadagni S, Fiorentini G,Cantore M.

Pancreas. 2008 Jan;36(1):56-60. doi: 10.1097/mpa.0b013e31812e9672.

Hypoxic pelvic and limb perfusion with melphalan and mitomycin C for recurrent limb melanoma: a pilot study.

Guadagni S, Santinami M, Patuzzo R, Pilati PL, Miotto D, Deraco M, Rossi CR, Fiorentini G, Di Filippo F, Valenti M, Amicucci G.

Melanoma Res. 2003 Feb;13(1):51-8.

IGEVO has also attained several congresses contributing with posters and oral presentations:

· Poster al Congresso CIRSE, September 7-11 2019, Barcelona, Spain: Preliminary results of Chemoembolization alone or associated to Bevacizumab for the therapy of colorectal cancer metastases (CRC): a randomized study Authors: G. Fiorentini, D. Sarti, M. Nardella, R. Inchingolo, M. Nestola, C. Aliberti, A. Rebonato.

· Poster al Congresso CIRSE (2018) September 22-25 Lisbon, Portugal: Importance of supportive therapy in transarterial chemoembolization (DEB-TACE) for metastatic liver cancers Type: Scientific Abstract Topic: Embolisation / GI tract intervention Authors: G. Fiorentini, D. Sarti, R. Carandina, S. Guadagni, C. Aliberti.

· Poster al Congresso CIRSE (2017) September 16-20, Copenhagen, Denmark: C. Aliberti, R. Carandina, D. Sarti, E. Pizzirani, G. Ramondo, L. Mulazzani, G. Fiorentini. Chemoembolization adopting polyethylene glycol drug-eluting embolics loaded with doxorubicin for the treatment of hepatocellular carcinoma

· Poster al Congresso CIRSE (2017) September 16-20, Copenhagen, Denmark: Aliberti, R. Carandina, D. Sarti, E. Pizzirani, G. Ramondo, L. Mulazzani, G. Fiorentini. Chemoembolization with drug-eluting beads loaded with doxorubicin for the treatment of Cholangiocarcinoma

· Poster al Congresso CIRSE (2017) September 16-20, Copenhagen, Denmark: Aliberti, R. Carandina, D. Sarti, E. Pizzirani, G. Ramondo, L. Mulazzani, GM Mattioli, G. Fiorentini. Trans radial access (TRA) for TACE and Hepatic Arterial Infusion Chemotherapy (HAIC) of Primary and metastatic liver cancer

· Poster presentato al congresso ESMO Madrid, Spain - 08 Sep - 12 Sep 2017: Giammaria Fiorentini, Donatella Sarti, Riccardo Carandina, Michele Nardella, Luca Mulazzani, Alessandro Felicioli, Daniel Barnés Navarro, Fernando M. Gomez, Odysseas Zoras, Camillo Aliberti. Polyethylene Glycol embolics loaded with irinotecan for chemoembolization of refractory liver metastases from colorectal cancer·

- Poster presentato al XIX congresso Nazionale AIOM (2017), Roma: Polyethylene Glycol embolics loaded with irinotecan for chemoembolization of refractory liver metastases from colorectal cancer

· Abstract accepted for oral presentation at the WCIO 2017 congress (Boston USA): Camillo Aliberti, Riccardo Carandina, Donatella Sarti, Luca Mulazzani, Enrico Pizzirani, Gaetano Ramondo, Giammaria Fiorentini Chemoembolization Adopting Polyethylene Glycol Drug-Eluting Embolics Loaded with Doxorubicin for the Treatment of Hepatocellular Carcinoma·

- Poster presentato al congresso WCIO 2017, Boston USA : Camillo Aliberti, Riccardo Carandina, Donatella Sarti, Luca Mulazzani, Enrico Pizzirani, Gaetano Ramondo, Giammaria Fiorentini. Polyethylene Glycol Embolics Loaded With Irinotecan for Chemoembolization of Metastatic Liver Cancer. Poster 82

· Poster presented on the occasion of CIRSE 2016, September 10-14, 2016 in Barcelona/ES: C. Aliberti, R. Carandina, D. Sarti, V. Catalano, L. Mulazzani, A. Felicioli, P. Coschiera, G. Fiorentini- Transarterial chemoembolization using polyethylene glycol drug-eluting beads pre-charged with doxorubicin (LIFDOX®) for the treatment of primary liver cancer: preliminary results.

· Poster presentato al XVIII congresso Nazionale AIOM (2016), Roma: Aliberti C, Carandina R, Sarti D, Mulazzani L, Catalano V, Felicioli A, Coschiera P, Fiorentini G. Hepatic Arterial Infusion of Polyethylene Glycol Drug-eluting Beads for Primary liver cancer therapy. Poster B24.

· Poster presentato al XVII congresso Nazionale AIOM (2015) Roma: Fiorentini G, Aliberti C, Sarti D, Coschiera P, Tilli M, Mulazzani L, Giordani P, Graziano F, Maques Gonzales A, Garcia Maros R, Gomez Mugnoz F, Cantore M, Ricci S, Catalano V, Mambrini A. DEBIRI and cetuximab (DEBIRITUX) as a secondline treatment for unresectable colorectal liver metastases (UCLM): results of a phase II trial exploring a new sequence

- 3rd ITLT Essen 2013 - Interdisciplinary Treatment of Liver Tumors in Essen, Germany : Complete Response of liver metastases (LM) from colorectal cancer (CRC) after intra-arterial hepatic chemotherapy (IAHC) with floxuridine (FLO) : outcome and perspectives.

- Turkey: presentation of IGEVO